Clinical Pharmacometrics

Pharmacometrics is the science of interpreting and describing pharmacology in a quantitative fashion. Clinical pharmacometrics covers the use of pharmacometrics in clinical pharmacology with a particular emphasis on applications to therapeutic use of drugs in humans.

Knowledge: Concepts applicable to studies of:

• pharmacokinetics and pharmacodynamics in vivo
• ligand binding and enzyme kinetics in vitro
• simulation and experimental design in silico
• target concentration intervention at the bedside

Skills: Ability to:

• Understand the kind of data required for simulation and parameter estimation
• Describe the components of a model
• Create models
  • Structural
    • Closed form expressions
    • Differential equations
  • Covariate
    • Size
    • Organ function
  • Error
    • Additive
    • Proportional
    • Additive+proportional
• Simulate model predictions and perform a sensitivity analysis
• Estimate parameters
  • Obtain initial estimates for parameter estimation
  • Individual
  • Population

Recommended Texts

Bourne, D.W.A. 1995. Mathematical Modeling of Pharmacokinetic Data, Technomic Publishing Company, Lancaster, PA ISBN 1-56676-204-9

Gabrielsson, J. and Weiner, D. 1997 Pharmacokinetic and Pharmacodynamic Data Analysis, Concepts and Applications, 2nd ed., Swedish Pharmaceutical Press. ISBN 91-8627-469-4

Peck CC, Conner DP, Murphy MG. 1989. Bedside Clinical Pharmacokinetics. Applied Therapeutics Inc, Vancouver, WA. ISBN: 0915486105

WWW Links

Pharmacometrics

Pharmacokinetics

PharmPK Mailing List

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Latest News

Improving Drug Development Using Patient Adherence Data in Clinical Trials, May 6-7, 2008.
Brochure (PDF)
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Advanced NONMEM workshop – March 17–19, 2008 at Mission Bay Conference Center, San Francisco, CA.
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UCSF-CDDS to launch The American Course on Drug Development and Regulatory Science- September 2007
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CDDS – Pharmacometric Services is available to drug researchers
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Howard Lee, MD, PhD, named Director of CDDS
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Lewis B. Sheiner Memorial. Symposium held at CDDS in December 2006
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